The establishment of the dendritic field is by nature a dynamic process as it is inevitably accompanied by dramatic changes in the morphology of entire dendritic arbors. Accurate neuronal wiring relies critically on the proper establishment of the dendritic field that is achieved by both structural build-ups of dendritic arbors and functional maturation of synapses ( Jan and Jan, 2010). In this article, we present our perspective view that impaired dendritic endocytic and secretory systems may contribute to dendritic pathology by encumbering PM turnover in NDs.ĭendrites are neuronal compartments essential for receiving electrochemical signals from presynaptic neurons through formed synapses. Supporting this notion, a growing body of literature provides evidence to suggest the pathogenic contribution of dysregulated PM turnover to dendritic pathology in certain NDs. To meet local demands, PM turnover in dendrites most likely requires local cellular machinery, such as dendritic endocytic and secretory systems, dysregulation of which may result in dendritic pathology observed in various neurodegenerative diseases (NDs). Because of the length and extensiveness of dendritic branches in neurons, the transport of materials needed for PM turnover from soma to distal dendrites will be inefficient and quite burdensome for somatic organelles. Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, South Koreaĭue to their enormous surface area compared to other cell types, neurons face unique challenges in properly handling supply and retrieval of the plasma membrane (PM)-a process termed PM turnover-in their distal areas.
Chang Geon Chung †, Sung Soon Park †, Jeong Hyang Park † and Sung Bae Lee *
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